Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
All Product Categories
-
Ligands for Target Protein for PROTAC Inhibitors
(3)
View all products
-
Ligands for Target Protein for PROTAC Chemicals
(6)
View all products
-
Ligands for Target Protein for PROTAC Degrader
(1)
View all products
-
Ligands for Target Protein for PROTAC Controls
(9)
View all products
-
Ligands for Target Protein for PROTAC Ligands
(12)
View all products
-
Ligands for Target Protein for PROTAC Related Products (679)
Related Products (679)
-
Related Compound Screening Libraries (1)
-
I-BET762 carboxylic acid (Standard)
0 ImagesCat. No.: HY-107443RCAS No.: 1300019-38-8Synonyms: Molibresib carboxylic acid (Standard); GSK525762A carboxylic acid (Standard); PROTAC BRD4-binding moiety 2 (Standard)I-BET762 carboxylic acid (Standard) is the analytical standard of I-BET762 carboxylic acid (HY-107443). This product is intended for research and analytical applications. I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1.
-
BRM/BRG1 ligand 1
0 ImagesCat. No.: HY-W539427CAS No.: 1893977-70-2
-
PROTAC BRD4-binding moiety 1 (Standard)
0 ImagesCat. No.: HY-107442RCAS No.: 2101200-10-4PROTAC BRD4-binding moiety 1 (Standard) is the analytical standard of PROTAC BRD4-binding moiety 1 (HY-107442). This product is intended for research and analytical applications. PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136). PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
SMARCA2/4-ligand-1
0 ImagesCat. No.: HY-159472CAS No.: 2411651-36-82-(6-Amino-5-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)phenol is a Ligand for target protein for pROTAC.
-
JH-I-25
0 ImagesCat. No.: HY-138834CAS No.: 1042673-20-0JH-I-25 is an orally active IRAK1 and IRAK4 inhibitor. JH-I-25 inhibits LPS-induced IRAK4 phosphorylation, IRAK1 degradation, MAPK activation, and the expression of proinflammatory cytokines TNF-α and IL-6 in lung tissues. JH-I-25 improves the survival rate of LPS-induced septic mice and serves as an IRAK4 recruiter in the design of proteolysis-targeting chimeric molecules. JH-I-25 can be used in research related to diffuse large B-cell lymphoma, Waldenström's macroglobulinemia, septic shock, rheumatoid arthritis, atherosclerosis, Alzheimer's disease, acute lung injury, sepsis, and psoriasis.
-
BRD4 ligand 13
0 ImagesCat. No.: HY-178094CAS No.: 1101702-81-1BRD4 ligand 13 is a BRD4 ligand that can be used for the synthesis of PROTACs, such as Cath-L-dBET1 (HY-173257). BRD4 ligand 13 is a target protein ligand-conjugate that can be used for the synthesis of PROTACs, such as SJH1-51B (HY-162240).
-
GNF-8625
0 ImagesCat. No.: HY-118271CAS No.: 1196546-33-4GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively.
-
ATM ligand-1
0 ImagesCat. No.: HY-185575CAS No.: 3056059-49-2ATM ligand-1 is an ATM ligand that can be used for the synthesis of PROTACs, such as PROTAC ATM degrader-1 (HY-158345).
-
SLF-amido-C2-COOH (Standard)
0 ImagesCat. No.: HY-107452RCAS No.: 1092369-24-8Synonyms: PROTAC FKBP12-binding moiety 1 (Standard)SLF-amido-C2-COOH (Standard) is the analytical standard of SLF-amido-C2-COOH (HY-107452). This product is intended for research and analytical applications. SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for FKBP (SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs.
